[{"content":"","externalUrl":null,"permalink":"/authors/","section":"Authors","summary":"","title":"Authors","type":"authors"},{"content":"","externalUrl":null,"permalink":"/categories/","section":"Categories","summary":"","title":"Categories","type":"categories"},{"content":"Email: cvizcarr@barnard.edu\nDepartment of Chemistry Barnard College 3009 Broadway New York, NY 10027\n","externalUrl":null,"permalink":"/contact/","section":"Vizcarra Lab","summary":"Email: cvizcarr@barnard.edu\nDepartment of Chemistry Barnard College 3009 Broadway New York, NY 10027\n","title":"Contact","type":"page"},{"content":" Principal Investigator # Christina Vizcarra\nAssociate Professor\nDepartment of Chemistry, Barnard College\nDownload CV (PDF) Lab Members # Erin Su\nBiochemistry, '27 Jacqueline Soraire\nChemistry, '28 Sylvia Lam\nundeclared, '29 Ceilna Li\nundeclared, '29 Alumni # Sofia Lebron — Biochemistry, \u0026lsquo;26\nAnna Pepper — Biochemistry, \u0026lsquo;26\nDeanna Wood — Biochemistry, \u0026lsquo;26\nCharlotte Ries — Biochemistry, \u0026lsquo;26\nAlanna Xue — Biochemistry, \u0026lsquo;26\nInanna Doytch — Biochemistry, \u0026lsquo;25 (with Austin lab)\nVanessa Yang — Biochemistry, \u0026lsquo;25\nSarah Jeanty — Biochemistry, \u0026lsquo;25\nSheikh Jobayar — Biochemistry, \u0026lsquo;24 (with Austin lab)\nNatasha Sharma — Biochemistry, \u0026lsquo;24 (with Olson lab)\nNingxin Luo — Biochemistry, \u0026lsquo;24\nKaren Jang — Biochemistry, \u0026lsquo;23 (with Austin lab)\nHana Illikkal — Biochemistry, \u0026lsquo;23\nXiang Ji — Biochemistry, \u0026lsquo;22 (with Olson lab)\nHannah Christianson — Chemistry, \u0026lsquo;22\nJoana Gjeci — Biochemistry, \u0026lsquo;22 (with Rojas lab)\nAliza Makovsky — Neuroscience \u0026amp; Behavior, \u0026lsquo;22 (with Olson lab)\nJulia Van Riel — Biochemistry, \u0026lsquo;22\nSophie Baum — Chemistry, \u0026lsquo;22 (with Austin lab)\nRahma Elsiesy — Biochemistry, \u0026lsquo;21 (with Austin lab)\nAmanda Klestzick — Biochemistry, \u0026lsquo;21\nDana Ross — Biochemistry, \u0026lsquo;21\nSpoorthi Balu — Biochemistry, \u0026lsquo;21 (with Austin lab)\nMehrose Ahmad — Biochemistry, \u0026lsquo;21 (with Austin lab)\nYeliz Sezgin — Biochemistry, \u0026lsquo;21 (with Austin lab)\nAngela Montero — Biochemistry, \u0026lsquo;20\nAlison Milano — Biochemistry, \u0026lsquo;20 (with Austin lab)\nVeronica Zelles — Biochemistry, \u0026lsquo;20\nShoshana Williams — Chemistry, \u0026lsquo;20 (with Austin lab)\nGrace Nickel — Biochemistry, \u0026lsquo;19\nCarla Hachicho — Biochemistry, \u0026lsquo;19 (with Austin lab)\nAisha Hasan — Chemistry, \u0026lsquo;18\nChristina Costeas — Biochemistry, \u0026lsquo;18\nLisette Garcia — Biochemistry, \u0026lsquo;18\nLisa Minkoff — Biochemistry, \u0026lsquo;18 (with Austin lab)\nArchana Nagarajan — Biochemistry, \u0026lsquo;17\nNeda Kashani — Biochemistry, \u0026lsquo;17\nTayyaba Jabeen — Biochemistry, \u0026lsquo;16\n","externalUrl":null,"permalink":"/people/","section":"Vizcarra Lab","summary":" Principal Investigator # Christina Vizcarra\nAssociate Professor\nDepartment of Chemistry, Barnard College\nDownload CV (PDF) Lab Members # Erin Su\nBiochemistry, '27 Jacqueline Soraire\nChemistry, '28 Sylvia Lam\nundeclared, '29 Ceilna Li\nundeclared, '29 Alumni # Sofia Lebron — Biochemistry, ‘26\n","title":"People","type":"page"},{"content":"Underline indicates a student researcher. * indicates a corresponding author.\nVizcarra CL, Trainor RF, McDonald AR, Richardson CT, Potoyan D, Nash JA, Lundgren B, Luchko T, Hocky GM, Foley JJ, Atherton TJ, Stokes GY* (2024) An interdisciplinary effort to integrate coding into science courses, Nature Computational Science, 4: 803–804. PubMed\nde Sousa Lobo Querido R, Ji X, Lakha R, Goodyear RJ, Richardson GP, Vizcarra CL, Olson ES* (2023) Visualizing collagen fibers in the tectorial and basilar membranes using CNA35, a fluorescently labelled bacterial-adhesion protein, Journal of the Association for Research in Otolaryngology, 24: 147–157. PubMed\nLakha R, Hachicho C, Mehlenbacher MR, Wilcox DE, Austin RN, Vizcarra CL* (2023) Metallothionein-3 attenuates the effect of Cu2+ ions on actin filaments, Journal of Inorganic Biochemistry, 242: 112157. PubMed\nOrman M, Landis M, Oza A, Nambiar D, Gjeci J, Song K, Huang V, Klestzick A, Hachicho C, Liu SQ, Kamm JM, Bartolini F, Vadakkan JJ, Rojas CM, Vizcarra CL* (2022) Alterations to the broad-spectrum formin inhibitor SMIFH2 modulate potency but not specificity, Scientific Reports, 12: 13520. PubMed\nMehlenbacher MR, Elsiesy R, Lakha R, Villones RL, Orman M, Vizcarra CL*, Meloni G*, Wilcox DE*, Austin RN* (2022) Metal Binding and Interdomain Thermodynamics of Mammalian Metallothionein 3: Enthalpically Favoured Cu+ Supplants Entropically Favoured Zn2+ to form Cu4+ Clusters Under Physiological Conditions, Chemical Science, 13: 5289–5304. PubMed\nWilliams SC, Luongo D, Orman M, Vizcarra CL, Austin RN* (2022) An alkane monooxygenase (AlkB) family in which all electron transfer partners are covalently bound to the oxygen-activating hydroxylase, Journal of Inorganic Biochemistry, 228: 111707. PubMed\nLakha R, Montero AM, Jabeen T, Costeas CC, Ma J, Vizcarra CL* (2021) Variable autoinhibition among deafness-associated variants of Diaphanous 1 (DIAPH1), Biochemistry, 60: 2320–2329. PubMed\nWilliams SC, Forsberg AP, Lee J, Vizcarra CL, Lopatkin AJ, Austin RN* (2021) Investigation of the prevalence and catalytic activity of rubredoxin-fused alkane monooxygenases (AlkBs), Journal of Inorganic Biochemistry, 219: 111409. PubMed\nVizcarra CL and Quinlan ME* (2017) Actin filament assembly by bacterial factors VopL/F: Which end is up?, Journal of Cell Biology, 216: 1211–1213. PubMed\nBradley AO, Vizcarra CL, Bailey H, Quinlan ME* (2020) Spire stimulates nucleation by Cappuccino and binds both ends of actin filaments, Molecular Biology of the Cell, 31: 273–286. PubMed\nSilkworth WT, Kunes KL, Nickel GC, Phillips ML, Quinlan ME*, Vizcarra CL* (2018) The Neuron Specific Formin Delphilin Nucleates but Does Not Enhance Actin Filament Elongation, Molecular Biology of the Cell, 29: 610–621. PubMed\nAhYoung AP, Koehl A, Vizcarra CL, Cascio D, Egea PF* (2016) Structure of a putative ClpS N-end rule adaptor protein from the malaria pathogen Plasmodium falciparum, Protein Science, 25: 689–701. PubMed\nOztug Durer ZA, McGillivary RM, Kang H, Elam WA, Vizcarra CL, Hanein D, De La Cruz EM, Reisler E, Quinlan ME* (2015) Metavinculin tunes the flexibility and the architecture of vinculin-induced bundles of actin filaments, Journal of Molecular Biology, 427: 2782–2798. PubMed\nVizcarra CL, Bor B, and Quinlan ME* (2014) The role of formin tails in actin nucleation, processive elongation, and filament bundling, Journal of Biological Chemistry, 289: 30602–30613. PubMed\nRoth-Johnson EA, Vizcarra CL, Bois JS, and Quinlan ME* (2014) Interaction between microtubules and the Drosophila formin Cappuccino and its effect on actin assembly, Journal of Biological Chemistry, 289: 4395–4404. PubMed\nBor B, Vizcarra CL, Phillips ML, and Quinlan ME* (2012) Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains, Molecular Biology of the Cell, 23: 3801–3813. PubMed\nChen MMY, Snow CD, Vizcarra CL, Mayo SL, and Arnold FH* (2012) Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes, Protein Engineering, Design \u0026amp; Selection, 25: 171–178. PubMed\nVizcarra CL†, Kreutz B†, Rodal AA, Toms AV, Lu J, Zheng W, Quinlan ME*, and Eck MJ* (2011) Structure and function of the interacting domains of Spire and Fmn-family formins, Proceedings of the National Academy of Sciences USA, 108: 11884–11889. (†Co-first authors) PubMed\nVizcarra CL, Zhang N, Marshall SA, Wingreen N, Zeng C, and Mayo SL* (2008) An improved pairwise decomposable finite difference Poisson-Boltzmann method for computational protein design, Journal of Computational Chemistry, 29: 1153–1162. PubMed\nTreynor TP, Vizcarra CL, Nedelcu D, and Mayo SL* (2007) Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of function, Proceedings of the National Academy of Sciences USA, 104: 48–53. PubMed\nMarshall SA, Vizcarra CL, and Mayo SL* (2005) One- and two-body decomposable Poisson-Boltzmann methods for protein design calculations, Protein Science, 14: 1293. PubMed\nVizcarra CL and Mayo SL* (2005) Electrostatics in Computational Protein Design, Current Opinion in Chemical Biology, 9: 622–626. PubMed\n","externalUrl":null,"permalink":"/publications/","section":"Vizcarra Lab","summary":"Underline indicates a student researcher. * indicates a corresponding author.\nVizcarra CL, Trainor RF, McDonald AR, Richardson CT, Potoyan D, Nash JA, Lundgren B, Luchko T, Hocky GM, Foley JJ, Atherton TJ, Stokes GY* (2024) An interdisciplinary effort to integrate coding into science courses, Nature Computational Science, 4: 803–804. PubMed\n","title":"Publications","type":"page"},{"content":" Formins \u0026 Microtubules\nWe are interested in the ubiquitous but cryptic interactions between microtubules and formins. Our goal is to map out the formin/microtubule interface and understand how that interface varies among formins. Formins \u0026 Small Molecules\nWe study the mechanistic basis for formin inhibition by small molecules with an eye toward developing the next generation of formin inhibitors. Auditory Protein Biochemistry\nWe study how deafness-associated variants impact formin function. Together with our collaborators in the Olson lab, we charactize other protein-based structures in the cochlea, including the tectorial membrane. Metallothioneins\nIn collaboration with the Austin lab, we study the interaction between metallothionein-3, copper ions, and the actin cytoskeleton. ","externalUrl":null,"permalink":"/research/","section":"Vizcarra Lab","summary":" Formins \u0026 Microtubules\nWe are interested in the ubiquitous but cryptic interactions between microtubules and formins. Our goal is to map out the formin/microtubule interface and understand how that interface varies among formins. Formins \u0026 Small Molecules\nWe study the mechanistic basis for formin inhibition by small molecules with an eye toward developing the next generation of formin inhibitors. Auditory Protein Biochemistry\nWe study how deafness-associated variants impact formin function. Together with our collaborators in the Olson lab, we charactize other protein-based structures in the cochlea, including the tectorial membrane. Metallothioneins\nIn collaboration with the Austin lab, we study the interaction between metallothionein-3, copper ions, and the actin cytoskeleton. ","title":"Research","type":"page"},{"content":"","externalUrl":null,"permalink":"/series/","section":"Series","summary":"","title":"Series","type":"series"},{"content":"","externalUrl":null,"permalink":"/tags/","section":"Tags","summary":"","title":"Tags","type":"tags"},{"content":"We are part of the Department of Chemistry at Barnard College.\nLearn more about our research, publications, and people, or get in touch.\n","externalUrl":null,"permalink":"/","section":"Vizcarra Lab","summary":"We are part of the Department of Chemistry at Barnard College.\nLearn more about our research, publications, and people, or get in touch.\n","title":"Vizcarra Lab","type":"page"}]