Formins & Microtubules
We are interested in the ubiquitous but cryptic interactions between microtubules and formins. Our goal is to map out the formin/microtubule interface and understand how that interface varies among formins.
We are interested in the ubiquitous but cryptic interactions between microtubules and formins. Our goal is to map out the formin/microtubule interface and understand how that interface varies among formins.
Formins & Small Molecules
We study the mechanistic basis for formin inhibition by small molecules with an eye toward developing the next generation of formin inhibitors.
We study the mechanistic basis for formin inhibition by small molecules with an eye toward developing the next generation of formin inhibitors.
Auditory Protein Biochemistry
We study how deafness-associated variants impact formin function. Together with our collaborators in the Olson lab, we charactize other protein-based structures in the cochlea, including the tectorial membrane.
We study how deafness-associated variants impact formin function. Together with our collaborators in the Olson lab, we charactize other protein-based structures in the cochlea, including the tectorial membrane.
Metallothioneins
In collaboration with the Austin lab, we study the interaction between metallothionein-3, copper ions, and the actin cytoskeleton.
In collaboration with the Austin lab, we study the interaction between metallothionein-3, copper ions, and the actin cytoskeleton.